Since nearly half a century ago, when dramatic and unprecedented changes in molecular biology and the recognition of cellular function was sparked by determination of the structure of DNA, the knowledge and understanding of biological macromolecules has accelerated via access to advanced methods. Nucleic acids store the cell information, but proteins have been found to be major players in the life of organisms, and in practice, almost all of the actual cell activities are carried out by proteins. It is, therefore, not surprising that following the completion of the Human Genome Project, the scientific community has thus turned its attention to proteins. On the one hand, following the advances developed in recombinant DNA technology, mass production of proteins is possible, and on the other hand, the development of protein purification techniques and access to accurate and advanced methods of analysis have made it possible to better understanding of the properties and complex structure of a protein. The application of advanced genomic and proteomics technologies has also paved the rapid selection of new peptides and proteins with a variety of therapeutic applications. Despite the increasing use of peptides and proteins in the treatment of many pathological diseases, the design of specific drug delivery systems for therapeutic purposes remain a major challenge for entering the clinical field, due to the inherent instability, structural complexity and therefore the need to maintain structural integrity for the biological activity of protein molecules. In recent years, much attention have been drawn by many researchers and pharmaceutical products formulators to conduct research on these issues.

Protein Technology Research Center (PTRC) was established as a joint-use research organization affiliated to Shahid Beheshti University of Medical Sciences in order to play a central role in protein science in Iran, with an emphasis on studies on the structure and function of proteins and their biological significance at the molecular and cellular levels; investigate chemistry and biochemistry of peptides & proteins (synthesis, purification, characterization and analysis of peptides & proteins); study the structure and stability of peptides & proteins;prepare and formulate protein delivery systems; produce recombinant products using biotechnology and evaluate the pharmacological effects of peptides & proteins. The initial application for the foundation of PTRC was submitted with the collaboration of:

 

  • Afshin Zarghi, Professor of Pharmaceutical/Medicinal Chemistry
  • Alireza Shafaati, Professor of Pharmaceutical/Medicinal Chemistry
  • Hamid Reza Moghimi, Professor of Pharmaceutics
  • Hassan Yazdanpanah, Professor of Pharmacology-Toxicology
  • Reza Aboofazali, Professor of Pharmaceutics

 

as the members of the Board of Founders and approved by the University Council in September 2011. The official establishment of PTRC was finally announced by the Council for Development of Medical Sciences Universities, Ministry of Health and Medical Education in Iran, in May 2012. To provide the facilities for mutual educational collaborations, making contributions to performing joint research and gathering a group of investigators interested in the broad field of protein research, PTRC has started its activity at School of Pharmacy, Shahid Beheshti University of Medical Sciences. PTRC would like to take this opportunity to kindly invite scientists and experts in the area of peptides and proteins in Iran and throughout the worlds for research collaboration.